Metal-free aerobic oxidative C-N bond cleavage of tertiary amines for the synthesis of N-heterocycles with high atom efficiency

An efficient metal-free aerobic oxidative C-N bond cleavage of tertiary amines has been developed to construct N-heterocycles using molecular oxygen as the sole oxidant with high atom efficiency, in which all of the three alkyl groups in tertiary amines can be utilized and transformed into N-heteroc...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2014-06, Vol.12 (23), p.3802-3807
Main Authors: Chen, Xiuling, Chen, Tieqiao, Zhou, Yongbo, Han, Daoqing, Han, Li-Biao, Yin, Shuang-Feng
Format: Article
Language:English
Subjects:
Aerobiosis
Amines - chemistry
Heterocyclic Compounds - chemistry
Metals - chemistry
Oxidation-Reduction
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Summary:An efficient metal-free aerobic oxidative C-N bond cleavage of tertiary amines has been developed to construct N-heterocycles using molecular oxygen as the sole oxidant with high atom efficiency, in which all of the three alkyl groups in tertiary amines can be utilized and transformed into N-heterocycles.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00578c