Metabolic syndrome and polycystic ovary syndrome: an intriguing overlapping

Abstract Metabolic syndrome is an increasing pathology in adults and in children, due to a parallel rise of obesity. Sedentary lifestyle, food habits, cultural influences and also a genetic predisposition can cause dyslipidemia, hypertension, abdominal obesity and insulin resistance which are the tw...

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Published in:Gynecological endocrinology 2014-06, Vol.30 (6), p.397-402
Main Authors: Caserta, Donatella, Adducchio, Gloria, Picchia, Simona, Ralli, Eleonora, Matteucci, Eleonora, Moscarini, Massimo
Format: Article
Language:English
Subjects:
Adiposity
BMI
Combined Modality Therapy
Female
HOMA
Humans
Insulin Resistance
Life Style
lifestyle
metabolic syndrome
Metabolic Syndrome - etiology
Metabolic Syndrome - prevention & control
Models, Biological
Obesity - metabolism
Obesity - pathology
Obesity - physiopathology
Obesity - therapy
PCOS
Polycystic Ovary Syndrome - etiology
Polycystic Ovary Syndrome - prevention & control
Polycystic Ovary Syndrome - therapy
Theca Cells - metabolism
Theca Cells - pathology
therapy
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Summary:Abstract Metabolic syndrome is an increasing pathology in adults and in children, due to a parallel rise of obesity. Sedentary lifestyle, food habits, cultural influences and also a genetic predisposition can cause dyslipidemia, hypertension, abdominal obesity and insulin resistance which are the two main features of metabolic syndrome. Polycystic ovary syndrome (PCOS) is a condition directly associated with obesity, insulin resistance (HOMA index) and metabolic syndrome, and it is very interesting for its relationship and overlap with the metabolic syndrome. The relationship between the two syndromes is mutual: PCOS women have a higher prevalence of metabolic syndrome and also women with metabolic syndrome commonly present the reproductive/endocrine trait of PCOS. Prevention and treatment of metabolic syndrome and PCOS are similar for various aspects. It is necessary to treat excess adiposity and insulin resistance, with the overall goals of preventing cardiovascular disease and type 2 diabetes and improving reproductive failure in young women with PCOS. First of all, lifestyle changes, then pharmacological therapy, bariatric surgery and laparoscopic ovarian surgery represent the pillars for PCOS treatment.
ISSN:0951-3590
1473-0766
DOI:10.3109/09513590.2014.887673