super(31)P spectroscopy in thrombolytic treatment of experimental cerebral infarct

Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil super(31)P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 1989-01, Vol.10 (1), p.47-52
Main Authors: Lee, BCP, Brock, J M, Fan, T, Seibert, A, Moonen, C, Kissel, P, Chehrazi, B, Bradbury, E M
Format: Article
Language:English
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Summary:Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil super(31)P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the super(31)P spectrum correlated with postmortem changes.
ISSN:0195-6108