Low serum bilirubin concentration is a predictor of chronic kidney disease

Abstract Objective Chronic kidney disease (CKD) is a worldwide public health problem. It is very important to identify the factors that affect CKD. Previous studies have reported that serum bilirubin concentration was positively correlated with renal function in a cross-sectional study. The aim of t...

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Published in:Atherosclerosis 2014-06, Vol.234 (2), p.421-425
Main Authors: Tanaka, Muhei, Fukui, Michiaki, Okada, Hiroshi, Senmaru, Takafumi, Asano, Mai, Akabame, Satoshi, Yamazaki, Masahiro, Tomiyasu, Ki-ichiro, Oda, Yohei, Hasegawa, Goji, Toda, Hitoshi, Nakamura, Naoto
Format: Article
Language:English
Subjects:
Adult
Antioxidant
Bilirubin
Bilirubin - blood
Biomarkers - blood
Cardiovascular
Chronic kidney disease
Disease Progression
Down-Regulation
Female
Glomerular Filtration Rate
Health Surveys
Humans
Japan - epidemiology
Kidney - physiopathology
Male
Middle Aged
Prognosis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Risk Factors
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Summary:Abstract Objective Chronic kidney disease (CKD) is a worldwide public health problem. It is very important to identify the factors that affect CKD. Previous studies have reported that serum bilirubin concentration was positively correlated with renal function in a cross-sectional study. The aim of this study was to investigate the relationship between serum bilirubin concentration and the progression of CKD. Methods A cohort study was performed on a consecutive series of 2784 subjects without CKD, defined as estimated glomerular filtration rate (eGFR) 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2014.03.015