Kinetic and steady-state characteristics of sodium channels modified by aconitine

Kinetic and steady-state characteristics of sodium channels of the Ranvier node membrane, modified by aconitine, were investigated by the voltage clamp method. Channels modified by aconitine were shown to be only partially inactivated. Dependence of the fraction of uninactivated channels on voltage...

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Bibliographic Details
Published in:Neurophysiology (New York) 1980-01, Vol.12 (6), p.404-408
Main Authors: Mozhaeva, G. N., Naumov, A. P., Nosyreva, E. D.
Format: Article
Language:English
Subjects:
aconitine
modification
nerves
Rana ridibunda
sodium
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Summary:Kinetic and steady-state characteristics of sodium channels of the Ranvier node membrane, modified by aconitine, were investigated by the voltage clamp method. Channels modified by aconitine were shown to be only partially inactivated. Dependence of the fraction of uninactivated channels on voltage can be described by a model of a channel with three states: closed, open, and inactivated. It is suggested that aconitine does not significantly change the parameters of the inactivated state. Repolarization of the membrane to between -70 and -110 mV after a long (10 msec) test shift of potential induces initially a rapid decline of the current ("tail") followed by a slow rise to the steady-state value. To explain the kinetics of this current it is necessary to postulate two or more more open states of the channel.
ISSN:0090-2977
1573-9007
DOI:10.1007/BF01066233