Modification of retinyl acetate toxicity in rats by coadministration of menhaden oil

Menhaden oil, which has hypolipidemic and anticarcinogenic activity, reduces the hypertriglyceridemia caused by retinyl acetate. Male Sprague-Dawley rats were dosed daily for 30 days by gavage with either corn oil (CO); menhaden oil (MO); 20, 80, and 250 mg/kg retinyl acetate (ROAc) in CO; or 20, 80...

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Bibliographic Details
Published in:Fundamental and applied toxicology 1989-04, Vol.12 (3), p.567-578
Main Authors: Lindamood, Charles, Thigpen, L.Mac, Giles, Herschell D., Makovec, G.T., McCarthy, Dennis J., Hill, Donald L.
Format: Article
Language:English
Subjects:
ACEITES DE PESCADO
Alkaline Phosphatase - blood
Animals
Biological and medical sciences
Body Weight - drug effects
Cholesterol - blood
Cytoplasm - drug effects
Cytoplasm - ultrastructure
Drug toxicity and drugs side effects treatment
Eating - drug effects
FISH OILS
Fish Oils - pharmacology
HUILE DE POISSON
Jejunum - anatomy & histology
Jejunum - drug effects
Male
Medical sciences
MENHADEN
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
RAT
RATA
RATS
Rats, Inbred Strains
RETINOL
TOXICIDAD
TOXICITE
TOXICITY
Triglycerides - blood
Vitamin A - analogs & derivatives
Vitamin A - toxicity
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Summary:Menhaden oil, which has hypolipidemic and anticarcinogenic activity, reduces the hypertriglyceridemia caused by retinyl acetate. Male Sprague-Dawley rats were dosed daily for 30 days by gavage with either corn oil (CO); menhaden oil (MO); 20, 80, and 250 mg/kg retinyl acetate (ROAc) in CO; or 20, 80, or 250 mg/kg ROAc in MO. Hypertriglyceridemia by ROAc was reduced by coadministration of MO, and serum cholesterol values were reduced to levels similar to those for rats receiving MO alone. Coadministration of MO reduced the ROAc-induced fracture incidence at 80 mg/kg but not at 250 mg/kg. For groups dosed with ROAc and CO or MO, there were no differences in weightgain depression, elevation of serum alkaline phosphatase, or reduction of food consumption, suggesting that reduced absorption of ROAc was not the basis for the activity of MO. The reduction in retinoid toxicity by MO suggests a need for further study of the toxicity and anticarcinogenicity of retinoid/menhaden oil combinations.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(89)90029-8