Weight variation over time and its relevance among multidrug-resistant tuberculosis patients

Summary Objectives We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. Methods This was a retrospective cohort study. The data of patients commencing MDR-TB therapy were analyzed. Data were collec...

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Bibliographic Details
Published in:International journal of infectious diseases 2014-06, Vol.23, p.20-24
Main Authors: Chung-Delgado, Kocfa, Revilla-Montag, Alejandro, Guillén-Bravo, Sonia, Bernabe-Ortiz, Antonio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antitubercular Agents - therapeutic use
Body Mass Index
Body Weight
Female
Follow-Up Studies
Humans
Infectious Disease
Male
Middle Aged
Multidrug-resistant tuberculosis
Peru - epidemiology
Pulmonary/Respiratory
Retrospective Studies
Treatment Outcome
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Weight
Young Adult
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Summary:Summary Objectives We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. Methods This was a retrospective cohort study. The data of patients commencing MDR-TB therapy were analyzed. Data were collected from different public TB treatment facilities located in peri-urban areas to the south of Lima, Peru. The outcome was patient body weight (kilograms) from treatment commencement, measured monthly. A random effects model was fitted using robust standard errors to calculate 95% confidence intervals. Results Of a total of 1242 TB cases, 243 (19.6%) were MDR-TB. Only 201 cases were included in the analysis; 127 (63.2%) were males and the mean patient age was 33.6 (standard deviation 16.2) years. Weight changes over time among the patients who were cured differed from changes in those who died during therapy ( p < 0.001). Weight curve divergence was important at the end of the third, fourth, and fifth treatment months: on average, the weight difference was 2.18 kg ( p < 0.001), 3.27 kg ( p = 0.007), and 3.58 kg ( p = 0.03), respectively, when cured patients were compared to those who died. Conclusions Our results show that weight variation during treatment can be a useful surrogate for the treatment outcome, specifically death during therapy. MDR-TB patients with weight loss should be followed more closely, as they are at greater risk of death.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2014.01.001