Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-06, Vol.24 (6), p.670-676
• Main Authors: Calanna, S, Scicali, R, Di Pino, A, Knop, F.K, Piro, S, Rabuazzo, A.M, Purrello, F
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein; Apolipoprotein A-I - blood; Body Composition; Cardiovascular; Cardiovascular risk; Cholesterol, HDL - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - metabolism; Diabetic Angiopathies - epidemiology; Dyslipidemias - complications; Dyslipidemias - epidemiology; Female; Glycated Hemoglobin A - analysis; Humans; Hypertension - complications; Hypertension - epidemiology; Insulin Resistance; Italy - epidemiology; Lipids - blood; Liver - diagnostic imaging; Liver steatosis; Male; Middle Aged; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Non-alcoholic Fatty Liver Disease - epidemiology; Non-alcoholic Fatty Liver Disease - physiopathology; Prediabetes; Prediabetic State - blood; Prediabetic State - complications; Prediabetic State - diagnosis; Prediabetic State - metabolism; Prevalence; Risk Factors; Severity of Illness Index; Type 2 diabetes; Ultrasonography
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2014.01.013

Abstract Background and aims We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Methods and results Ninety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39–46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% (