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Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes
Abstract Background and aims We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Methods and results Ninety-one subjects with prediabetes according to HbA1c, i.e. fro...
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| Published in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-06, Vol.24 (6), p.670-676 |
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| container_title | Nutrition, metabolism, and cardiovascular diseases |
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| creator | Calanna, S Scicali, R Di Pino, A Knop, F.K Piro, S Rabuazzo, A.M Purrello, F |
| description | Abstract Background and aims We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Methods and results Ninety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39–46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% ( |
| doi_str_mv | 10.1016/j.numecd.2014.01.013 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1529840162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0939475314000441</els_id><sourcerecordid>1529840162</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-3d31717c9dc9071a0aac535b5f71e16dee09df6ae9ce2a89487e2f30a6c08d603</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6D0T66KXHqiTdmVyEZfELBjyo4C2kk2rN2J1uk-6F-femmV0PXoSChPC8VeQpxl4i7BGwfXPax3Uk5_ccUO4BS4lHbIeNhloorh-zHWiha6kaccWe5XwCEAqEfMquuGybFoXese_HMAdf2eirIdxRqmwXpzTaISyBchVi9dPSOP0Ypq7cb9DVnvoQyVdzIh9sR0vBtvhynqni1cPbc_akt0OmF_fnNfv2_t3X24_18fOHT7c3x9pJVEstvECFymnvNCi0YK1rRNM1vULC1hOB9n1rSTvi9qDlQRHvBdjWwcG3IK7Z60vfOU2_V8qLGUN2NAw20rRmgw3XB1mE8YLKC-rSlHOi3swpjDadDYLZnJqTuTg1m1MDWEqU2Kv7CWs3kv8bepBYgLcXgMo_7wIlk12g6IqfRG4xfgr_m_BvAzeEGJwdftGZ8mlaUywODZrMDZgv2163taIEAClR_AFY955i</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529840162</pqid></control><display><type>article</type><title>Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Calanna, S ; Scicali, R ; Di Pino, A ; Knop, F.K ; Piro, S ; Rabuazzo, A.M ; Purrello, F</creator><creatorcontrib>Calanna, S ; Scicali, R ; Di Pino, A ; Knop, F.K ; Piro, S ; Rabuazzo, A.M ; Purrello, F</creatorcontrib><description>Abstract Background and aims We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Methods and results Ninety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39–46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% (<39 mmol/mol), were studied. Fasting blood samples for lipid profiles, fatty liver index (FLI), bioimpedance analysis, ultrasound scan of the liver, and BARD (body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes) score for evaluation of liver fibrosis, were performed in all subjects. In comparison to controls, subjects with prediabetes were characterised by: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure, triglycerides levels and apolipoprotein B/apolipoprotein AI ratio, higher FLI, increased prevalence of and more severe hepatic steatosis, similar BARD score, and higher total body fat mass. In comparison to subjects with diabetes, subjects with prediabetes exhibited: similar blood pressure and apolipoprotein B/apolipoprotein AI ratio, similar FLI, reduced prevalence of and less severe hepatic steatosis, lower BARD score, increased percent fat and lower total body muscle mass. In comparison to controls, subjects with diabetes showed: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure and triglycerides levels, higher FLI, increased prevalence of and more severe hepatic steatosis, higher BARD score, and higher total body muscle mass. Moreover, HbA1c was correlated with BMI, HOMA-IR, triglycerides, HDL cholesterol, AST, and ALT. Conclusions Subjects with HbA1c-defined prediabetes and type 2 diabetes, respectively, are characterised by abnormalities in lipid profile and liver steatosis, thus exhibiting a severe risk profile for cardiovascular and liver diseases.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2014.01.013</identifier><identifier>PMID: 24656139</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Apolipoprotein ; Apolipoprotein A-I - blood ; Body Composition ; Cardiovascular ; Cardiovascular risk ; Cholesterol, HDL - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - metabolism ; Diabetic Angiopathies - epidemiology ; Dyslipidemias - complications ; Dyslipidemias - epidemiology ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Hypertension - complications ; Hypertension - epidemiology ; Insulin Resistance ; Italy - epidemiology ; Lipids - blood ; Liver - diagnostic imaging ; Liver steatosis ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Non-alcoholic Fatty Liver Disease - epidemiology ; Non-alcoholic Fatty Liver Disease - physiopathology ; Prediabetes ; Prediabetic State - blood ; Prediabetic State - complications ; Prediabetic State - diagnosis ; Prediabetic State - metabolism ; Prevalence ; Risk Factors ; Severity of Illness Index ; Type 2 diabetes ; Ultrasonography</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2014-06, Vol.24 (6), p.670-676</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3d31717c9dc9071a0aac535b5f71e16dee09df6ae9ce2a89487e2f30a6c08d603</citedby><cites>FETCH-LOGICAL-c417t-3d31717c9dc9071a0aac535b5f71e16dee09df6ae9ce2a89487e2f30a6c08d603</cites><orcidid>0000-0003-0689-1759</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24656139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calanna, S</creatorcontrib><creatorcontrib>Scicali, R</creatorcontrib><creatorcontrib>Di Pino, A</creatorcontrib><creatorcontrib>Knop, F.K</creatorcontrib><creatorcontrib>Piro, S</creatorcontrib><creatorcontrib>Rabuazzo, A.M</creatorcontrib><creatorcontrib>Purrello, F</creatorcontrib><title>Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Methods and results Ninety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39–46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% (<39 mmol/mol), were studied. Fasting blood samples for lipid profiles, fatty liver index (FLI), bioimpedance analysis, ultrasound scan of the liver, and BARD (body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes) score for evaluation of liver fibrosis, were performed in all subjects. In comparison to controls, subjects with prediabetes were characterised by: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure, triglycerides levels and apolipoprotein B/apolipoprotein AI ratio, higher FLI, increased prevalence of and more severe hepatic steatosis, similar BARD score, and higher total body fat mass. In comparison to subjects with diabetes, subjects with prediabetes exhibited: similar blood pressure and apolipoprotein B/apolipoprotein AI ratio, similar FLI, reduced prevalence of and less severe hepatic steatosis, lower BARD score, increased percent fat and lower total body muscle mass. In comparison to controls, subjects with diabetes showed: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure and triglycerides levels, higher FLI, increased prevalence of and more severe hepatic steatosis, higher BARD score, and higher total body muscle mass. Moreover, HbA1c was correlated with BMI, HOMA-IR, triglycerides, HDL cholesterol, AST, and ALT. Conclusions Subjects with HbA1c-defined prediabetes and type 2 diabetes, respectively, are characterised by abnormalities in lipid profile and liver steatosis, thus exhibiting a severe risk profile for cardiovascular and liver diseases.</description><subject>Adult</subject><subject>Apolipoprotein</subject><subject>Apolipoprotein A-I - blood</subject><subject>Body Composition</subject><subject>Cardiovascular</subject><subject>Cardiovascular risk</subject><subject>Cholesterol, HDL - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetic Angiopathies - epidemiology</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - epidemiology</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - epidemiology</subject><subject>Insulin Resistance</subject><subject>Italy - epidemiology</subject><subject>Lipids - blood</subject><subject>Liver - diagnostic imaging</subject><subject>Liver steatosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Non-alcoholic Fatty Liver Disease - physiopathology</subject><subject>Prediabetes</subject><subject>Prediabetic State - blood</subject><subject>Prediabetic State - complications</subject><subject>Prediabetic State - diagnosis</subject><subject>Prediabetic State - metabolism</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Type 2 diabetes</subject><subject>Ultrasonography</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkU2LFDEQhoMo7rj6D0T66KXHqiTdmVyEZfELBjyo4C2kk2rN2J1uk-6F-femmV0PXoSChPC8VeQpxl4i7BGwfXPax3Uk5_ccUO4BS4lHbIeNhloorh-zHWiha6kaccWe5XwCEAqEfMquuGybFoXese_HMAdf2eirIdxRqmwXpzTaISyBchVi9dPSOP0Ypq7cb9DVnvoQyVdzIh9sR0vBtvhynqni1cPbc_akt0OmF_fnNfv2_t3X24_18fOHT7c3x9pJVEstvECFymnvNCi0YK1rRNM1vULC1hOB9n1rSTvi9qDlQRHvBdjWwcG3IK7Z60vfOU2_V8qLGUN2NAw20rRmgw3XB1mE8YLKC-rSlHOi3swpjDadDYLZnJqTuTg1m1MDWEqU2Kv7CWs3kv8bepBYgLcXgMo_7wIlk12g6IqfRG4xfgr_m_BvAzeEGJwdftGZ8mlaUywODZrMDZgv2163taIEAClR_AFY955i</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Calanna, S</creator><creator>Scicali, R</creator><creator>Di Pino, A</creator><creator>Knop, F.K</creator><creator>Piro, S</creator><creator>Rabuazzo, A.M</creator><creator>Purrello, F</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0689-1759</orcidid></search><sort><creationdate>20140601</creationdate><title>Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes</title><author>Calanna, S ; Scicali, R ; Di Pino, A ; Knop, F.K ; Piro, S ; Rabuazzo, A.M ; Purrello, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3d31717c9dc9071a0aac535b5f71e16dee09df6ae9ce2a89487e2f30a6c08d603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Apolipoprotein</topic><topic>Apolipoprotein A-I - blood</topic><topic>Body Composition</topic><topic>Cardiovascular</topic><topic>Cardiovascular risk</topic><topic>Cholesterol, HDL - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetic Angiopathies - epidemiology</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - epidemiology</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - epidemiology</topic><topic>Insulin Resistance</topic><topic>Italy - epidemiology</topic><topic>Lipids - blood</topic><topic>Liver - diagnostic imaging</topic><topic>Liver steatosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Non-alcoholic Fatty Liver Disease - diagnostic imaging</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Non-alcoholic Fatty Liver Disease - physiopathology</topic><topic>Prediabetes</topic><topic>Prediabetic State - blood</topic><topic>Prediabetic State - complications</topic><topic>Prediabetic State - diagnosis</topic><topic>Prediabetic State - metabolism</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Type 2 diabetes</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calanna, S</creatorcontrib><creatorcontrib>Scicali, R</creatorcontrib><creatorcontrib>Di Pino, A</creatorcontrib><creatorcontrib>Knop, F.K</creatorcontrib><creatorcontrib>Piro, S</creatorcontrib><creatorcontrib>Rabuazzo, A.M</creatorcontrib><creatorcontrib>Purrello, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calanna, S</au><au>Scicali, R</au><au>Di Pino, A</au><au>Knop, F.K</au><au>Piro, S</au><au>Rabuazzo, A.M</au><au>Purrello, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>24</volume><issue>6</issue><spage>670</spage><epage>676</epage><pages>670-676</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aims We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Methods and results Ninety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39–46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% (<39 mmol/mol), were studied. Fasting blood samples for lipid profiles, fatty liver index (FLI), bioimpedance analysis, ultrasound scan of the liver, and BARD (body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes) score for evaluation of liver fibrosis, were performed in all subjects. In comparison to controls, subjects with prediabetes were characterised by: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure, triglycerides levels and apolipoprotein B/apolipoprotein AI ratio, higher FLI, increased prevalence of and more severe hepatic steatosis, similar BARD score, and higher total body fat mass. In comparison to subjects with diabetes, subjects with prediabetes exhibited: similar blood pressure and apolipoprotein B/apolipoprotein AI ratio, similar FLI, reduced prevalence of and less severe hepatic steatosis, lower BARD score, increased percent fat and lower total body muscle mass. In comparison to controls, subjects with diabetes showed: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure and triglycerides levels, higher FLI, increased prevalence of and more severe hepatic steatosis, higher BARD score, and higher total body muscle mass. Moreover, HbA1c was correlated with BMI, HOMA-IR, triglycerides, HDL cholesterol, AST, and ALT. Conclusions Subjects with HbA1c-defined prediabetes and type 2 diabetes, respectively, are characterised by abnormalities in lipid profile and liver steatosis, thus exhibiting a severe risk profile for cardiovascular and liver diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24656139</pmid><doi>10.1016/j.numecd.2014.01.013</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0689-1759</orcidid></addata></record> |
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| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2014-06, Vol.24 (6), p.670-676 |
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| subjects | Adult Apolipoprotein Apolipoprotein A-I - blood Body Composition Cardiovascular Cardiovascular risk Cholesterol, HDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - metabolism Diabetic Angiopathies - epidemiology Dyslipidemias - complications Dyslipidemias - epidemiology Female Glycated Hemoglobin A - analysis Humans Hypertension - complications Hypertension - epidemiology Insulin Resistance Italy - epidemiology Lipids - blood Liver - diagnostic imaging Liver steatosis Male Middle Aged Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnostic imaging Non-alcoholic Fatty Liver Disease - epidemiology Non-alcoholic Fatty Liver Disease - physiopathology Prediabetes Prediabetic State - blood Prediabetic State - complications Prediabetic State - diagnosis Prediabetic State - metabolism Prevalence Risk Factors Severity of Illness Index Type 2 diabetes Ultrasonography |
| title | Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes |
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