Reverse Dipper and High Night-time Heart Rate in Acute Stage of Cerebral Infarction Are Associated with Increased Mortality

• Published in: Journal of stroke and cerebrovascular diseases 2014-05, Vol.23 (5), p.1171-1176
• Main Authors: Park, Jae-Hyeong, MD, PhD, Lee, Hyun-Seok, MD, Kim, Jun Hyung, MD, Lee, Jae-Hwan, MD, PhD, Kim, Jei, MD, PhD, Choi, Si Wan, MD, PhD
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Aged, 80 and over; ambulatory blood pressure monitoring; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular; Cerebral infarction; Cerebral Infarction - diagnosis; Cerebral Infarction - mortality; Cerebral Infarction - physiopathology; Circadian Rhythm; Female; Heart Rate; Humans; hypertension; Hypertension - diagnosis; Hypertension - mortality; Hypertension - physiopathology; Kaplan-Meier Estimate; Male; Middle Aged; mortality; Multivariate Analysis; Neurology; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2013.10.010

Background Reverse dipper, blood pressure (BP) rises during night-time, is a risk factor of increased cardiovascular events in hypertensive patients. However, we have little information whether reverse dipper in acute stage of cerebral infarction (CI) affects on the recurrence and mortality. We studied to assess the relationship between reverse dipper and adverse clinical outcomes in the acute stage of CI. Methods We screened and enrolled consecutive patients with acute CI with ambulatory blood pressure monitoring (ABPM) within 2 weeks after admission from August 2001 to July 2005. According to systolic blood pressure (SBP) dropping pattern during night-time compared with daytime, we classified into extreme dipper (≥20%), dipper (≥10%,