Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia

Several studies have proposed telomere length and telomerase activity as prognostic factors in chronic lymphocytic leukemia (CLL), whereas information addressing the role of telomere‐associated genes is limited. We measured relative telomere length (RTL) and TERT expression levels in purified periph...

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Bibliographic Details
Published in:Genes chromosomes & cancer 2014-07, Vol.53 (7), p.612-621
Main Authors: Hoxha, Mirjam, Fabris, Sonia, Agnelli, Luca, Bollati, Valentina, Cutrona, Giovanna, Matis, Serena, Recchia, Anna Grazia, Gentile, Massimo, Cortelezzi, Agostino, Morabito, Fortunato, Bertazzi, Pier Alberto, Ferrarini, Manlio, Neri, Antonino
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
B-Lymphocytes - metabolism
Case-Control Studies
DNA Methylation
Gene Expression Profiling
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Middle Aged
Retrospective Studies
Telomerase - genetics
Telomerase - metabolism
Telomere - genetics
Telomere Shortening
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Summary:Several studies have proposed telomere length and telomerase activity as prognostic factors in chronic lymphocytic leukemia (CLL), whereas information addressing the role of telomere‐associated genes is limited. We measured relative telomere length (RTL) and TERT expression levels in purified peripheral CD19+ B‐cells from seven healthy donors and 77 untreated CLLs in early stage disease (Binet A). Data were correlated with the major biological and cytogenetic markers, global DNA methylation (Alu and LINE‐1), and clinical outcome. The expression profiles of telomere‐associated genes were also investigated. RTL was decreased in CLLs as compared with controls (P 
ISSN:1045-2257
1098-2264
DOI:10.1002/gcc.22171