Factors affecting sonographic preoperative local staging of endometrial cancer

• Published in: Ultrasound in obstetrics & gynecology 2014-05, Vol.43 (5), p.575-585
• Main Authors: Fischerova, D., Frühauf, F., Zikan, M., Pinkavova, I., Kocián, R., Dundr, P., Nemejcova, K., Dusek, L., Cibula, D.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Body Mass Index; Cell Movement; cervical stromal invasion; Cervix Uteri - diagnostic imaging; Cervix Uteri - pathology; Endometrial cancer; Endometrial Neoplasms - diagnostic imaging; Endometrial Neoplasms - pathology; Female; FIGO staging; Histology; Humans; Middle Aged; myometrial invasion; Myometrium - diagnostic imaging; Myometrium - pathology; Neoplasm Invasiveness; Neoplasm Staging; Preoperative Care - methods; Prospective Studies; Reproducibility of Results; transvaginal sonography; Ultrasonography; ultrasound; Women
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.13248

ABSTRACT Objectives To identify major factors in the under‐ and overestimation of cervical and myometrial invasion by endometrial cancer at preoperative staging by ultrasound. Methods This prospective study involved all patients with histologically confirmed endometrial cancer referred consecutively for surgical staging between January 2009 and December 2011. All patients underwent transvaginal ultrasound examination, obtaining metric and perfusion data, and the results were compared with final histology: myometrial invasion was defined at histology in the final pathology report as being either < or ≥ 50%, while cervical stromal invasion was reported as being either present or absent, and sonographic over‐/underestimation was determined relative to these. Results Enrolled prospectively into the study were 210 patients. The proportion of cases with sonographic underestimation, relative to final histology, of myometrial invasion (i.e. false‐negative estimation of no or superficial invasion