A structure-function approach to investigate the role of inflammatory cells and mediators in the production of acute lung injury

This communication suggests one approach to study acute lung injury in an integrated, coordinated manner using a combination of human and animal studies; in vivo and in vitro approaches; and physiologic, morphologic, pharmacologic, cellular, and biochemical techniques. The authors suggest that such...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1988, Vol.524 (1), p.271-281
Main Authors: Peters, S.P, Albertine, K.H, Gee, M.H, Gottlieb, J.E
Format: Article
Language:English
Subjects:
Acute Disease
AGENTES NOCIVOS
Animals
FACTEUR NUISIBLE
FUNCTIONAL DISORDERS
GENERO HUMANO
GENRE HUMAIN
Humans
INFLAMACION
INFLAMMATION
INJURIOUS FACTORS
Leukotriene B4 - physiology
LUNGS
MANKIND
Neutrophils - drug effects
Neutrophils - physiology
OVIN
OVINOS
PATHOGENESE
PATHOGENESIS
PATOGENESIS
POUMON
PULMONES
RESPIRATORY DISORDERS
Respiratory Distress Syndrome, Adult - metabolism
Respiratory Distress Syndrome, Adult - pathology
Respiratory Distress Syndrome, Adult - physiopathology
SHEEP
SRS-A - physiology
Tetradecanoylphorbol Acetate - pharmacology
TRASTORNOS FUNCIONALES
TRASTORNOS RESPIRATORIOS
TROUBLE FONCTIONNEL
TROUBLE RESPIRATOIRE
Vasoconstriction
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Summary:This communication suggests one approach to study acute lung injury in an integrated, coordinated manner using a combination of human and animal studies; in vivo and in vitro approaches; and physiologic, morphologic, pharmacologic, cellular, and biochemical techniques. The authors suggest that such an approach will be needed to shed light on the pathophysiology of this disorder and suggest criteria that could be useful for applying these various techniques. The authors review their preliminary observations made using this approach. Lastly, they speculate on the importance of perturbations of cellular function and regulation in contributing to acute lung injury and to complications of this syndrome.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1988.tb38550.x