Cardiovascular effects of and interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs. VI: Verapamil and fentanyl-pancuronium

To assess the interaction between verapamil and fentanyl-pancuronium, dogs were chronically instrumented to measure heart rate; PR interval; aortic, left ventricular, and left atrial pressures; and coronary, carotid, and renal blood flows. The effect of fentanyl citrate infusion on single-dose verap...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1988-06, Vol.68 (6), p.874-879
Main Authors: HILL, D. C, CHELLY, J. E, ABDALLAH DLEWATI, ABERNETHY, D. R, DOURSOUT, M.-F, MERIN, R. G
Format: Article
Language:English
Subjects:
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Dogs
Drug Interactions
Fentanyl - pharmacology
Hemodynamics - drug effects
Medical sciences
Neuropharmacology
Pancuronium - pharmacology
Pharmacology. Drug treatments
Verapamil - pharmacokinetics
Verapamil - pharmacology
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Summary:To assess the interaction between verapamil and fentanyl-pancuronium, dogs were chronically instrumented to measure heart rate; PR interval; aortic, left ventricular, and left atrial pressures; and coronary, carotid, and renal blood flows. The effect of fentanyl citrate infusion on single-dose verapamil pharmacokinetics was examined in six animals. The effects of verapamil infusion (3 micrograms.kg-1.min-1 and 6 micrograms.kg-1.min-1) were examined in the conscious state and during fentanyl infusion plus pancuronium on two separate occasions in nine dogs. In addition, the effects of fentanyl citrate (500 micrograms.kg-1 followed by 1.5 micrograms.kg-1.min-1) were examined over 1 h of infusion. Fentanyl infusion did not affect single-dose verapamil pharmacokinetics. In the conscious animals, verapamil increased heart rate and PR interval, and slightly decreased LV dP/dt. Fentanyl combined with pancuronium increased mean arterial pressure and LV dP/dt. During fentanyl infusion, verapamil decreased mean arterial pressure and LV dP/dt, increased PR interval, and did not change heart rate. The hemodynamic effects of fentanyl infusion were steady over 1 h. In contrast to the inhalational anesthetics, which alter verapamil pharmacokinetics and have mainly additive effects with verapamil on left ventricular contractility, cardiac conduction, and regional blood flows, fentanyl-pancuronium had no effect on verapamil pharmacokinetics and minimal effect on verapamil pharmacodynamics in healthy dogs.
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198806000-00007