Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment

• Published in: Graefe's archive for clinical and experimental ophthalmology 2014-06, Vol.252 (6), p.881-888
• Main Authors: Loukovaara, Sirpa, Lehti, Kaisa, Robciuc, Alexandra, Pessi, Timo, Holopainen, Juha M., Koli, Katri, Immonen, Ilkka, Keski-Oja, Jorma
• Format: Article
• Language: English
• Subjects: Aged; Angiopoietin-1 - metabolism; Angiopoietin-2 - metabolism; Biomarkers - metabolism; Enzyme-Linked Immunosorbent Assay; Erythropoietin - metabolism; Female; Humans; Male; Matrix Metalloproteinases - metabolism; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Prospective Studies; Retinal Detachment - diagnosis; Retinal Detachment - metabolism; Retinal Disorders; Transforming Growth Factor beta1 - metabolism; Vascular Endothelial Growth Factor A - metabolism; Vitreous Body - metabolism
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-013-2508-z

Purpose To explore factors related to pathogenesis of rhegmatogenous retinal detachment (RRD) and development of proliferative vitreoretinopathy (PVR), vitreous levels of angiopoietin-1 and −2 (Ang-1 and −2), previously undefined in RRD, transforming growth factor-(TGF) β1, vascular endothelial growth factor (VEGF), erythropoietin (EPO) and proteolytic mediators of extracellular matrix remodelling (MMP-2 and −9) were compared in eyes with RRD and eyes with idiopathic macular hole or pucker. Methods Vitreous samples were collected from 117 eyes with RRD (study group) and 40 eyes with macular hole or pucker (control group). Growth factors were measured by ELISA and matrix metalloproteinases (MMPs) by gelatin zymography. Results The mean vitreous concentrations of Ang-2, MMP-2, and MMP-9 were higher (all p