Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A sub(1)-adenosine receptors

Sulfur-containing analogues of 8-substituted xanthines were prepared in an effort to increase selectivity or potency as antagonists at adenosine receptors. Either cyclopentyl or various aryl substituents were utilized at the 8-position, because of the association of these group with high potency at...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1989-01, Vol.32 (8), p.1873-1879
Main Authors: Jacobson, KA, Kiriasis, L, Barone, S, Bradbury, B J, Kammula, U, Campagne, J M, Secunda, S, Daly, J W, Neumeyer, J L
Format: Article
Language:English
Subjects:
1,3-dialkylxanthine
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Summary:Sulfur-containing analogues of 8-substituted xanthines were prepared in an effort to increase selectivity or potency as antagonists at adenosine receptors. Either cyclopentyl or various aryl substituents were utilized at the 8-position, because of the association of these group with high potency at A sub(1)-adenosine receptors.
ISSN:0022-2623