Vgr-1, a Mammalian Gene Related to Xenopus Vg-1, is a Member of the Transforming Growth Factor β Gene Superfamily

The transforming growth factor β (TGF-β )-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to X...

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Published in:Proceedings of the National Academy of Sciences - PNAS 1989-06, Vol.86 (12), p.4554-4558
Main Authors: Lyons, Karen, Graycar, Jeannette L., Lee, Angela, Hashmi, Sofie, Lindouist, Patricia B., Chen, Ellson Y., Brigid L. M. Hogan, Derynck, Rik
Format: Article
Language:English
Subjects:
Aging
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Cell lines
Cellular differentiation
Complementary DNA
Developmental biology
Drosophila - genetics
Embryos
Endoderm
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Gin
Messenger RNA
Mice
Mice, Inbred ICR - growth & development
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Multigene Family
Organ Specificity
RNA
Sequence Homology, Nucleic Acid
Species Specificity
Transforming Growth Factors - genetics
Xenopus
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container_end_page 4558
container_issue 12
container_start_page 4554
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 86
creator Lyons, Karen
Graycar, Jeannette L.
Lee, Angela
Hashmi, Sofie
Lindouist, Patricia B.
Chen, Ellson Y.
Brigid L. M. Hogan
Derynck, Rik
description The transforming growth factor β (TGF-β )-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-β superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.
doi_str_mv 10.1073/pnas.86.12.4554
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identifier ISSN: 0027-8424
ispartof Proceedings of the National Academy of Sciences - PNAS, 1989-06, Vol.86 (12), p.4554-4558
issn 0027-8424
1091-6490
language eng
recordid cdi_proquest_miscellaneous_15307514
source PubMed Central Free; JSTOR
subjects Aging
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Cell lines
Cellular differentiation
Complementary DNA
Developmental biology
Drosophila - genetics
Embryos
Endoderm
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Gin
Messenger RNA
Mice
Mice, Inbred ICR - growth & development
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Multigene Family
Organ Specificity
RNA
Sequence Homology, Nucleic Acid
Species Specificity
Transforming Growth Factors - genetics
Xenopus
title Vgr-1, a Mammalian Gene Related to Xenopus Vg-1, is a Member of the Transforming Growth Factor β Gene Superfamily
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