Evaluation of Bioactive Components and Antioxidant and Anticancer Properties of Citrus Wastes Generated during Bioethanol Production

In the bioethanol production process employing citrus peels, a large amount of enzymatic hydrolyzed residues is generated as waste material. The bioactive compounds, and antioxidant and anticancer activities of these residues were investigated in the present study. Hydrolyzed citrus residues exhibit...

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Bibliographic Details
Published in:Natural product communications 2014-04, Vol.9 (4), p.483-486
Main Authors: Im, Soon Jae, Kim, Jae-Hoon, Kim, Min Young
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants - chemistry
Biofuels - analysis
Carcinoma
Cell Line, Tumor
Cell Survival - drug effects
Citrus - chemistry
Colonic Neoplasms
Dose-Response Relationship, Drug
Ethanol - chemistry
Flavanones - chemistry
Flavonols - chemistry
Humans
Melanoma
Solid Waste - analysis
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Summary:In the bioethanol production process employing citrus peels, a large amount of enzymatic hydrolyzed residues is generated as waste material. The bioactive compounds, and antioxidant and anticancer activities of these residues were investigated in the present study. Hydrolyzed citrus residues exhibited similar antioxidant activity as the unhydrolyzed control, which was positively correlated to the contents of total phenols, flavonoids and total carotenoid. Some flavonoids (naringin, naringenin, hesperetin and neohesperidin) and two high value co-products (D-limonene and galacturonic acid) were detected only in hydrolyzed residues. In addition, hydrolyzed residues showed antiproliferative activity and sub-Gl arrest in human melanoma A375 and colon cancer HCT116 cells. These results provide an alternative use for hydrolyzed citrus residues in the functional food, cosmetic and pharmaceutical industries.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1400900413