RAD51 G135C gene polymorphism and risk of colorectal cancer in Kashmir

• Published in: European journal of cancer prevention 2014-07, Vol.23 (4), p.264-268
• Main Authors: Nissar, Saniya, Baba, Shahid M., Akhtar, Tahseena, Rasool, Roohi, Shah, Zaffar A., Sameer, Aga Syed
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - genetics; Biological and medical sciences; Carcinoma, Squamous Cell - genetics; Case-Control Studies; Colorectal Neoplasms - genetics; Female; Genetic Predisposition to Disease; Humans; India; Male; Medical sciences; Middle Aged; Miscellaneous; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Odds Ratio; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Rad51 Recombinase - genetics; Research paper; Tumors
• ISSN: 0959-8278; 1473-5709
• DOI: 10.1097/CEJ.0000000000000049

RAD51 – a DNA double-strand breaks repair gene plays an important role in homologous recombination, a process frequently involved in cancer transformation. The aim of this study was to compare the distribution of the genotype of the RAD51 G135C polymorphism between colorectal cancer (CRC) patients and controls. We also tested the association between the G135C polymorphism of the RAD51 gene and the risk of CRC, and various clinicopathological parameters. Polymorphism was evaluated by restriction fragment length polymorphism PCR in 100 CRC patients and 120 age-matched and sex-matched controls. There was a significant association between RAD51 genotypes and CRC cases (P3.84). Our results suggest that the G135C polymorphism of the RAD51 gene is associated with an increased risk of CRC in our population.