Can intravesical bacillus Calmette-Guerin reduce recurrence in patients with non-muscle invasive bladder cancer？ An update and cumulative meta-analysis

Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder...

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Bibliographic Details
Published in:Frontiers of medicine 2014-06, Vol.8 (2), p.241-249
Main Authors: Pan, Jiangang, Liu, Mo, Zhou, Xing
Format: Article
Language:English
Subjects:
Administration, Intravesical
bacillus Calmette-Guérin (BCG)
BCG Vaccine - administration & dosage
BCG Vaccine - therapeutic use
Bladder cancer
Health risk assessment
Humans
Medicine
Medicine & Public Health
Meta-analysis
non-muscle invasive bladder cancer
Randomized Controlled Trials as Topic
Recurrence
Research Article
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - prevention & control
卡介苗
复发
患者
浸润性
累积
肌
膀胱癌
辅助治疗
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Summary:Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-014-0328-0