The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading

Summary In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relatio...

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Published in:Clinical physiology and functional imaging 2014-05, Vol.34 (3), p.218-229
Main Authors: Weber, Tobias, Ducos, Michel, Mulder, Edwin, Beijer, Åsa, Herrera, Frankyn, Zange, Jochen, Degens, Hans, Bloch, Wilhelm, Rittweger, Jörn
Format: Article
Language:English
Subjects:
Adult
arterial blood flow
Biomechanical Phenomena
Blood Flow Velocity
Femoral Artery - diagnostic imaging
Femoral Artery - physiopathology
Humans
Lactic Acid - blood
Leg
Male
Muscle Contraction
Muscle Fatigue
muscle perfusion
muscle power
Muscle Strength
muscle unloading
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Muscular Atrophy - blood
Muscular Atrophy - pathology
Muscular Atrophy - physiopathology
Orthotic Devices
Regional Blood Flow
Time Factors
Torque
Ultrasonography
Weight-Bearing
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Summary:Summary In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relation to arterial blood flow and muscle perfusion. Eleven male subjects (31 ± 6 years) wore the HEPHAISTOS unloading orthosis unilaterally for 56 days. It allows habitual ambulation while greatly reducing plantar flexor activity and torque production. Endpoint measurements encompassed arterial blood flow, measured in the femoral artery using Doppler ultrasound, oxygenation of the soleus muscle assessed by near‐infrared spectroscopy, lactate concentrations determined in capillary blood and muscle activity using soleus muscle surface electromyography. Furthermore, soleus muscle biopsies were taken to investigate morphological muscle changes. After the intervention, maximal isokinetic torque was reduced by 23·4 ± 8·2% (P
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12087