Advances in chiral separations by nonaqueous capillary electrophoresis in pharmaceutical and biomedical analysis

NACE is an alternative technique to aqueous CE in the chiral separations of partially soluble racemates. Besides, partially water‐soluble or insoluble chiral selectors may be exploited in the enantiomeric resolution in NACE. The high reproducibility due to low Joule heat generation and no change in...

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Bibliographic Details
Published in:Electrophoresis 2014-04, Vol.35 (7), p.926-936
Main Authors: Ali, Imran, Sanagi, Mohd Marsin, Aboul-Enein, Hassan Y.
Format: Article
Language:English
Subjects:
Chiral recognition mechanism
Chiral selectors
Chiral separations
Electrophoresis
Electrophoresis, Capillary - methods
Electrophoresis, Capillary - trends
Mathematical analysis
Non-aqueous capillary electrophoresis
Organic Chemicals - analysis
Organic Chemicals - chemistry
Organic Chemicals - isolation & purification
Organic solvents
Pharmaceutical and biomedical analysis
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - isolation & purification
Pharmaceuticals
Recognition
Reproducibility
Selectors
Separation
Solvents
Stereoisomerism
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Summary:NACE is an alternative technique to aqueous CE in the chiral separations of partially soluble racemates. Besides, partially water‐soluble or insoluble chiral selectors may be exploited in the enantiomeric resolution in NACE. The high reproducibility due to low Joule heat generation and no change in BGE concentration may make NACE a routine analytical technique. These facts attracted scientists to use NACE for the chiral resolution. The present review describes the advances in the chiral separations by NACE and its application in pharmaceutical and biomedical analysis. The emphasis has been given to discuss the selection of the chiral selectors and organic solvents, applications of NACE, comparison between NACE and aqueous CE, and chiral recognition mechanism. Besides, efforts have also been made to predict the future perspectives of NACE.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.201300222