Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system

Fate determination of neural crest cells is an essential step for the development of different crest cell derivatives. Peripheral glia development is marked by the choice of the neural crest cells to differentiate along glial lineages. The molecular mechanism underlying fate acquisition is poorly un...

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Bibliographic Details
Published in:Cellular signalling 2014-04, Vol.26 (4), p.673-682
Main Authors: Kipanyula, Maulilio John, Kimaro, Wahabu Hamisi, Yepnjio, Faustin N., Aldebasi, Yousef H., Farahna, Mohammed, Nwabo Kamdje, Armel Herve, Abdel-Magied, Eltuhami M., Seke Etet, Paul Faustin
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Embryonic stem cells
Glia development
Neural Crest - cytology
Neural Crest - metabolism
Neural crest cells
Neuregulin-1
Neuregulin-1 - metabolism
Neuroglia - cytology
Neuroglia - metabolism
Notch
Peripheral Nervous System - metabolism
Receptors, Notch - metabolism
Signal Transduction
Sox 10
SOXE Transcription Factors - metabolism
Stem Cells - cytology
Stem Cells - metabolism
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Summary:Fate determination of neural crest cells is an essential step for the development of different crest cell derivatives. Peripheral glia development is marked by the choice of the neural crest cells to differentiate along glial lineages. The molecular mechanism underlying fate acquisition is poorly understood. However, recent advances have identified different transcription factors and genes required for the complex instructive signaling process that comprise both local environmental and cell intrinsic cues. Among others, at least the roles of Sox10, Notch, and neuregulin 1 have been documented in both in vivo and in vitro models. Cooperative interactions of such factors appear to be necessary for the switch from multipotent neural crest cells to glial lineage precursors in the peripheral nervous system. This review summarizes recent advances in the understanding of fate determination of neural crest cells into different glia subtypes, together with the potential implications in regenerative medicine. •An intrinsic NCSC differentiation program may pre-determine NCSC lineages.•Microenvironment originating key signaling molecules also affect NCSC fate.•NCSC-derived progenitors could be directed to other NCSC derivative stem cell types.•Unraveling mechanisms determining NCSCs fate is crucial in regenerative medicine.
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2013.12.007