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Novel synthetic routes to N-(2-amino-9H-purin-6-yl)-substituted amino acids

Reaction of N2-protected 2-amino-6-chloropurine with tert-butyl (S)-phenylalaninate, (R)- and (S)-valinates followed by deprotection affords 2-aminopurines bearing at 6-position the corresponding amino acid moieties, whose chiral centre is partially racemized.

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Bibliographic Details
Published in:Mendeleev communications 2014-01, Vol.24 (1), p.35-36
Main Authors: Vigorov, Alexey Yu, Krasnov, Viktor P., Gruzdev, Dmitry A., Men'shikova, Alisa A., Demin, Alexander M., Levit, Galina L., Charushin, Valery N.
Format: Article
Language:English
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Summary:Reaction of N2-protected 2-amino-6-chloropurine with tert-butyl (S)-phenylalaninate, (R)- and (S)-valinates followed by deprotection affords 2-aminopurines bearing at 6-position the corresponding amino acid moieties, whose chiral centre is partially racemized.
ISSN:0959-9436
DOI:10.1016/j.mencom.2013.12.011