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Novel synthetic routes to N-(2-amino-9H-purin-6-yl)-substituted amino acids
Reaction of N2-protected 2-amino-6-chloropurine with tert-butyl (S)-phenylalaninate, (R)- and (S)-valinates followed by deprotection affords 2-aminopurines bearing at 6-position the corresponding amino acid moieties, whose chiral centre is partially racemized.
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Published in: | Mendeleev communications 2014-01, Vol.24 (1), p.35-36 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Reaction of N2-protected 2-amino-6-chloropurine with tert-butyl (S)-phenylalaninate, (R)- and (S)-valinates followed by deprotection affords 2-aminopurines bearing at 6-position the corresponding amino acid moieties, whose chiral centre is partially racemized. |
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ISSN: | 0959-9436 |
DOI: | 10.1016/j.mencom.2013.12.011 |