Effect of gamma radiation on the transport of spin-labeled compounds across the erythrocyte membrane

The effect of ionizing radiation on the non-electrolyte, anion and cation permeability of the erythrocyte membrane was studied by measurement of the reduction rate of appropriate nitroxyl derivatives. Irradiation of bovine erythrocytes in the dose-range of 2-50 krad resulted in a regular dose-depend...

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Bibliographic Details
Published in:Radiation and environmental biophysics 1981-01, Vol.19 (4), p.275-285
Main Authors: Gwoździński, K, Bartosz, G, Leyko, W
Format: Article
Language:English
Subjects:
Animals
Biological Transport - radiation effects
Cattle
Choline - analogs & derivatives
Choline - metabolism
Cyclic N-Oxides - metabolism
Dose-Response Relationship, Radiation
Erythrocyte Membrane - metabolism
erythrocytes
Erythrocytes - metabolism
Extracellular Space - metabolism
gamma radiation
Gamma Rays
Kinetics
Mathematics
Piperidines - metabolism
Spin Labels - metabolism
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Summary:The effect of ionizing radiation on the non-electrolyte, anion and cation permeability of the erythrocyte membrane was studied by measurement of the reduction rate of appropriate nitroxyl derivatives. Irradiation of bovine erythrocytes in the dose-range of 2-50 krad resulted in a regular dose-dependent increase in the reduction rates of a cation (TEMPO-choline) and a hydrophobic non-electrolyte (TEMPO), and non-regular changes in the reduction rate of a hydrophilic non-electrolyte (TEMPOL). The permeation constant for TEMPO-choline also showed a non-regular response to radiation, similar to the response pattern of other red blood cell parameters. These results also demonstrate that the effects of radiation on the transport of various solutes can be used as a means of distinguishing between different channels of membrane transport.
ISSN:0301-634X
1432-2099
DOI:10.1007/BF01324093