Succinate: a metabolic signal in inflammation

Highlights • NAD+ , citrate, and succinate are a novel class of metabolites with inflammatory signaling capacity. • Succinate is elevated in inflammation and sustains IL-1β production through HIF-1α stabilization. • Succinate activates immune cells via its receptor SUCNR1 and exacerbates disease. •...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2014-05, Vol.24 (5), p.313-320
Main Authors: Mills, Evanna, O’Neill, Luke A.J
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Citric Acid Cycle
HIF-1α
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - physiology
Immunity, Innate
inflammation
Inflammation - metabolism
Inflammation Mediators - metabolism
metabolism
Pathology
Protein Processing, Post-Translational
Receptors, G-Protein-Coupled - physiology
Signal Transduction
succinate
Succinic Acid - metabolism
succinylation
SUCNR1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • NAD+ , citrate, and succinate are a novel class of metabolites with inflammatory signaling capacity. • Succinate is elevated in inflammation and sustains IL-1β production through HIF-1α stabilization. • Succinate activates immune cells via its receptor SUCNR1 and exacerbates disease. • Succinylation is a new post-translational modification that affects enzyme function.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.11.008