Comment on "Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach"

The present manuscript is a comment on the article entitled "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harma...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2014-07, Vol.136, p.26-28
Main Authors: Alomar, Maria L, Gonzalez, M Micaela, Erra-Balsells, Rosa, Cabrerizo, Franco M
Format: Article
Language:English
Subjects:
DNA - chemistry
Harmaline - analogs & derivatives
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Summary:The present manuscript is a comment on the article entitled "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA.
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2014.04.017