Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers

Ultraviolet radiation absorbed by the epidermis is the major cause of various cutaneous disorders, including photoaging and skin cancers. Although topical sunscreens may offer proper skin protection, dietary plant compounds may significantly contribute to lifelong protection of skin health, especial...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2014-07, Vol.136, p.12-18
Main Authors: Pérez-Sánchez, A, Barrajón-Catalán, E, Caturla, N, Castillo, J, Benavente-García, O, Alcaraz, M, Micol, V
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cell Line
Cell Survival - drug effects
Citrus paradisi
Comet Assay
Diterpenes - pharmacology
Diterpenes - therapeutic use
DNA Damage - drug effects
Erythema - etiology
Erythema - prevention & control
Female
Flavonoids - pharmacology
Flavonoids - therapeutic use
Healthy Volunteers
Humans
Keratinocytes - metabolism
Keratinocytes - radiation effects
Male
Middle Aged
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polyphenols - pharmacology
Polyphenols - therapeutic use
Protective Agents - pharmacology
Protective Agents - therapeutic use
Reactive Oxygen Species - metabolism
Rosmarinus
Skin - radiation effects
Ultraviolet Rays - adverse effects
X-Rays - adverse effects
Young Adult
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Summary:Ultraviolet radiation absorbed by the epidermis is the major cause of various cutaneous disorders, including photoaging and skin cancers. Although topical sunscreens may offer proper skin protection, dietary plant compounds may significantly contribute to lifelong protection of skin health, especially when unconsciously sun UV exposed. A combination of rosemary and citrus bioflavonoids extracts was used to inhibit UV harmful effects on human HaCaT keratinocytes and in human volunteers after oral intake. Survival of HaCaT cells after UVB radiation was higher in treatments using the combination of extracts than in those performed with individual extracts, indicating potential synergic effects. The combination of extracts also decreased UVB-induced intracellular radical oxygen species (ROS) and prevented DNA damage in HaCaT cells by comet assay and decreased chromosomal aberrations in X-irradiated human lymphocytes. The oral daily consumption of 250 mg of the combination by human volunteers revealed a significant minimal erythema dose (MED) increase after eight weeks (34%, p
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2014.04.007