Immunologic response and safety in birch pollen sublingual versus oral vestibule immunotherapy: A pilot study

The lower limits of the 95% CI of the difference V - S were -0.075 or more except for week 24. [...]noninferiority could be concluded posttreatment and at week 36, respectively. Because of the hierarchically ordered sequence of confirmatory tests, no additional adjustment for multiplicity was requir...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2014-06, Vol.133 (6), p.1757-1759.e3
Main Authors: Allam, Jean-Pierre, MD, Wuestenberg, Eike, MD, Wolf, Hendrik, PhD, Klimek, Ludger, MD, Decot, Elke, MD, Horn, Andreas, MD, Schnitker, Jörg, PhD, Bieber, Thomas, MD, PhD, MDRA, Novak, Natalija, MD
Format: Article
Language:English
Subjects:
Administration, Oral
Administration, Sublingual
Allergens - administration & dosage
Allergens - immunology
Allergies
Allergy and Immunology
Asthma
Betula - adverse effects
Desensitization, Immunologic
Humans
Immunotherapy
Pilot Projects
Pollen
Pollen - immunology
Rhinitis, Allergic, Seasonal - immunology
Rhinitis, Allergic, Seasonal - therapy
Studies
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Summary:The lower limits of the 95% CI of the difference V - S were -0.075 or more except for week 24. [...]noninferiority could be concluded posttreatment and at week 36, respectively. Because of the hierarchically ordered sequence of confirmatory tests, no additional adjustment for multiplicity was required.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.03.026