Changes in bone Pb accumulation: Cause and effect of altered bone turnover

• Published in: Bone (New York, N.Y.) N.Y.), 2014-07, Vol.64, p.228-234
• Main Authors: Brito, José A.A, Costa, Isabel M, e Silva, Alexandra Maia, Marques, José M.S, Zagalo, Carlos M, Cavaleiro, Inês I.B, Fernandes, Tânia A.P, Gonçalves, Luísa L
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Biomarkers - metabolism; Bone and Bones - metabolism; Bone Remodeling; Bone turnover; Diseases of the osteoarticular system; Female; Fundamental and applied biological sciences. Psychology; Half-Life; Kinetic models; Lead - metabolism; Lead - pharmacokinetics; Medical sciences; Orthopedics; Osteoporosis; Osteoporosis. Osteomalacia. Paget disease; Pb exposure; Rats; Rats, Wistar; Skeleton and joints; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: osteoarticular system, musculoskeletal system
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2014.04.021

Abstract This paper assesses the magnitude of Pb uptake in cortical and trabecular bones in healthy animals and animals with altered balance in bone turnover, and the impact of exposure to Pb on serum markers of bone formation and resorption. The results reported herein provide physiological evidence that Pb distributes differently in central compartments in Pb metabolism, such as cortical and trabecular bones, in healthy animals and animals with altered balance in bone turnover, and that exposure to Pb does have an impact on bone resorption resulting in OC-dependent osteopenia. These findings show that Pb may play a role in the etiology of osteoporosis and that its concentration in bones varies as a result of altered bone turnover characteristic of this disease, a long standing question in the field. In addition, data collected in this study are consistent with previous observations of increased half-life of Pb in bone at higher exposures. This evidence is relevant for the necessary revision of current physiologically based kinetic models for Pb in humans.