Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia

Highlights • Sarcosine preconditioning reduced hippocampal cell death after cerebral ischemia. • Sarcosine preconditioning reduced glycine content and uptake in the hippocampus. • Sarcosine preconditioning reduced GlyT-1 and GlyT-2 expression in the hippocampus. • Sarcosine preconditioning reduced t...

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Bibliographic Details
Published in:Neuroscience 2014-06, Vol.271, p.160-169
Main Authors: Pinto, M.C.X, Simão, F, da Costa, F.L.P, Rosa, D.V, de Paiva, M.J.N, Resende, R.R, Romano-Silva, M.A, Gomez, M.V, Gomez, R.S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Ischemia - drug therapy
Brain Ischemia - pathology
Brain Ischemia - physiopathology
brain preconditioning
Cell Death - drug effects
Cell Death - physiology
cerebral ischemia
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Glycine - metabolism
Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors
Glycine Plasma Membrane Transport Proteins - metabolism
Hippocampus - drug effects
Hippocampus - pathology
Hippocampus - physiopathology
Male
Medical sciences
Neurology
Neurons - drug effects
Neurons - pathology
Neurons - physiology
neuroprotection
Neuroprotective Agents - pharmacology
neurotransmission and glycine transporter type 1
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - metabolism
Sarcosine - pharmacology
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Summary:Highlights • Sarcosine preconditioning reduced hippocampal cell death after cerebral ischemia. • Sarcosine preconditioning reduced glycine content and uptake in the hippocampus. • Sarcosine preconditioning reduced GlyT-1 and GlyT-2 expression in the hippocampus. • Sarcosine preconditioning reduced the expression of NR2B-containing NMDA receptors. • Sarcosine preconditioning induced ischemic tolerance against cerebral ischemia.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.04.054