Release of super(3)H-5-hydroxytryptamine by amiflamine and related phenylalkylamines from rat occipital cortex slices

In the present study amiflamine and other related reversible monoamine oxidase-A (MAO-A) inhibitory phenylalkylamines were examined in vitro for their ability to induce release of super(3)H-5-hydroxytryptamine ( super(3)H-5-HT) from rat occipital cortex slices. It is concluded that compounds which w...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1989-01, Vol.339 (6), p.684-689
Main Authors: Ask, A-L, Fagervall, I, Huang, R-B, Ross, S B
Format: Article
Language:English
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Summary:In the present study amiflamine and other related reversible monoamine oxidase-A (MAO-A) inhibitory phenylalkylamines were examined in vitro for their ability to induce release of super(3)H-5-hydroxytryptamine ( super(3)H-5-HT) from rat occipital cortex slices. It is concluded that compounds which were effective releasers of 5-HT in vitro were those that are transported into the serotonergic neurons by the 5-HT carrier in vivo and has in addition an ability to mobilise vesicular 5-HT.
ISSN:0028-1298