Adenine nucleotides regulate Ca super(2+) transport in brain mitochondria

Adenine nucleotides (ADP > ATP) greatly enhance Ca super(2+) uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca super(2+) down to cellular free Ca super(2+) levels, suggesting a role for mitochondria in modulating Ca super(2+)...

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Bibliographic Details
Published in:FEBS letters 1989-01, Vol.247 (2), p.483-486
Main Authors: Rottenberg, H, Marbach, M
Format: Article
Language:English
Online Access:Get full text
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Summary:Adenine nucleotides (ADP > ATP) greatly enhance Ca super(2+) uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca super(2+) down to cellular free Ca super(2+) levels, suggesting a role for mitochondria in modulating Ca super(2+) cycles in brain cells. Analysis of the effects of various inhibitors on Ca super(2+) uptake and efflux suggest that locking the ADP/ATP translocator in its M-state stimulates electrogenic Ca super(2+) uptake and, to a lesser extent, inhibits Ca super(2+) efflux. It is suggested that this effect is due to a modulation of the surface charge on the M-side which enhances Ca super(2+) dissociation from the carriers.
ISSN:0014-5793