Induction of cytotoxic T cells as a novel independent survival factor in malignant melanoma with percutaneous peptide immunization

Highlights • Tumor specific CTLs were induced by attaching peptides on the barrier-disrupted skin. • OS of the complete responders was longer than that of the incomplete responders. • The induction of CTLs was a novel independent survival factor.

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Bibliographic Details
Published in:Journal of dermatological science 2014-07, Vol.75 (1), p.43-48
Main Authors: Fujiyama, Toshiharu, Oze, Isao, Yagi, Hiroaki, Hashizume, Hideo, Matsuo, Keitaro, Hino, Ryosuke, Kamo, Riei, Imayama, Shuhei, Hirakawa, Satoshi, Ito, Taisuke, Takigawa, Masahiro, Tokura, Yoshiki
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adult
Aged
Cancer Vaccines - administration & dosage
Cancer Vaccines - immunology
Cytotoxic T lymphocytes
Dermatology
Female
gp100 Melanoma Antigen - administration & dosage
HLA Antigens - immunology
Humans
Immunization
Male
MART-1 Antigen - administration & dosage
Melanoma
Melanoma - drug therapy
Melanoma - immunology
Melanoma - mortality
Melanoma - pathology
Melanoma-Specific Antigens - administration & dosage
Middle Aged
Monophenol Monooxygenase - administration & dosage
Multivariate Analysis
Peptide Fragments - administration & dosage
Peptide Fragments - immunology
Percutaneous peptide immunization
Proportional Hazards Models
Prospective Studies
Skin Neoplasms - drug therapy
Skin Neoplasms - immunology
Skin Neoplasms - mortality
Skin Neoplasms - pathology
T-Lymphocytes, Cytotoxic - drug effects
T-Lymphocytes, Cytotoxic - immunology
Time Factors
Treatment Outcome
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Description
Summary:Highlights • Tumor specific CTLs were induced by attaching peptides on the barrier-disrupted skin. • OS of the complete responders was longer than that of the incomplete responders. • The induction of CTLs was a novel independent survival factor.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2014.04.005