Interaction of the Antitumour Drug 4'-(9-Acridinylamino)-Methanesulfon-m-Anisidine. HCl (m-AMSA) With Nucleic Acids

The interaction of AMSA with nucleic acids was studied by several techniques. Melting temperature and CD studies equally suggest that AMSA-binding is interfering with the secondary structure of DNA. An overlap by two mechanism of binding seems to exist. Based on the CD measurements at low drug conce...

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Bibliographic Details
Published in:Nucleic acids research 1981-01, Vol.9 (24), p.6959-6973
Main Authors: Hudecz, F, Kajtar, J, Szekerke, M
Format: Article
Language:English
Online Access:Get full text
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Summary:The interaction of AMSA with nucleic acids was studied by several techniques. Melting temperature and CD studies equally suggest that AMSA-binding is interfering with the secondary structure of DNA. An overlap by two mechanism of binding seems to exist. Based on the CD measurements at low drug concentration intercalation is the most likely way of binding. At higher drug concentration stacking interaction predominates leading to cooperativity and formation of oriented sheets of aromatic ring-systems as reflected in the optical activity induced in the metachromatic band of the achiral drug.
ISSN:0305-1048