Teaghrelins, Unique Acylated Flavonoid Tetraglycosides in Chin-Shin Oolong Tea, Are Putative Oral Agonists of the Ghrelin Receptor

Chin-shin oolong tea, a popular tea in Taiwan, was empirically perceived to induce hunger and accelerate gastric emptying in a manner similar to the physiological effects of ghrelin, an endogenous acylated peptide known as the hunger hormone. Two unique acylated flavonoid tetraglycosides previously...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2014-06, Vol.62 (22), p.5085-5091
Main Authors: Lo, Yuan-Hao, Chen, Ying-Jie, Chang, Chi-I, Lin, Yi-Wen, Chen, Chung-Yu, Lee, Maw-Rong, Lee, Viola S. Y, Tzen, Jason T. C
Format: Article
Language:English
Subjects:
Acylation
agonists
Animals
antagonists
anterior pituitary
bile
Camellia sinensis - chemistry
dose response
Eating - drug effects
flavonoids
Flavonoids - chemistry
Flavonoids - pharmacology
food intake
gastric emptying
ghrelin
Ghrelin - metabolism
ghrelin receptors
Glycosides - chemistry
Glycosides - pharmacology
hormone secretion
hunger
intravenous injection
Male
metabolites
oolong tea
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Ghrelin - agonists
Receptors, Ghrelin - metabolism
somatotropin
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Summary:Chin-shin oolong tea, a popular tea in Taiwan, was empirically perceived to induce hunger and accelerate gastric emptying in a manner similar to the physiological effects of ghrelin, an endogenous acylated peptide known as the hunger hormone. Two unique acylated flavonoid tetraglycosides previously identified in Chin-shin oolong tea were demonstrated to induce hunger of rats in a food intake assay and, thus, named teaghrelin-1 and teaghrelin-2. Similar to GHRP-6, a synthetic analogue of ghrelin, teaghrelin-1 stimulated growth hormone secretion of rat primary anterior pituitary cells in a dose-dependent manner, and the stimulation was inhibited by [d-Arg1,d-Phe5,d-Trp7,9,Leu11]-substance P, an antagonist of the ghrelin receptor. While teaghrelin-2 remained unmodified, a meta-O-methylated metabolite of teaghrelin-1 was detected in bile of rats after intravenous injection. Presumably, teaghrelins are promising oral agonists of the ghrelin receptor.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf501425m