HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia

• Published in: Oral diseases 2014-07, Vol.20 (5), p.440-445
• Main Authors: Allon, I, Kaplan, I, Allon, DM, Vered, H, Shlomi, B, Hirshberg, A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Dentistry; epithelial growth factor receptor (EGFR); Female; Humans; hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - physiology; hypoxia-inducible factor alpha (HIF-1α); Immunohistochemistry; Male; Middle Aged; necrotizing sialometaplasia; Receptor, Epidermal Growth Factor - physiology; Salivary Glands - chemistry; Sialometaplasia, Necrotizing - etiology; vascular endothelial growth factor (VEGF); Vascular Endothelial Growth Factor A - physiology
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/odi.12149

Objectives Necrotizing sialometaplasia (NS) is an uncommon reactive lesion involving the minor salivary glands. This study aimed to investigate the expression of hypoxia‐inducible factor alpha (HIF‐1α), vascular endothelial growth factor (VEGF), and epithelial growth factor receptor (EGFR) in the pathogenesis of NS. Methods Paraffin‐embedded tissue sections from 10 cases of NS were immunohistochemically stained for HIF‐1α, VEGF, and EGFR. A semiquantitative morphometric analysis was performed and compared with normal palatal salivary glands and traumatic ulcerations. Results Hypoxia‐inducible factor alpha staining was observed in most elements of the affected area, the acini and ducts of the involved salivary glands as well as in the inflammatory infiltrate, the endothelial cells, and stromal cells. HIF‐1α was almost absent in the control glands (P