Lipid landscapes and pipelines in membrane homeostasis

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting feature...

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Bibliographic Details
Published in:Nature (London) 2014-06, Vol.510 (7503), p.48-57
Main Authors: Holthuis, Joost C.M., Menon, Anant K.
Format: Article
Language:English
Subjects:
631/45
631/80
Animals
Biological control systems
Carrier Proteins - metabolism
Cell adhesion & migration
Homeostasis
Humanities and Social Sciences
Humans
Intracellular Membranes - chemistry
Intracellular Membranes - metabolism
Intracellular Membranes - secretion
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Lipid metabolism
Lipids
Membrane Lipids - analysis
Membrane Lipids - biosynthesis
Membrane Lipids - chemistry
Membrane Lipids - metabolism
Membranes
multidisciplinary
Organelles - chemistry
Organelles - metabolism
Organelles - secretion
Physical properties
Physiological aspects
Physiological research
Plasma
Proteins
review-article
Science
Solute movement
Sphingolipids - metabolism
Sterols
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Summary:The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature13474