Comparison of the In Vitro and In Vivo Dissolution Rates of Two Diuranates and Research on an Early Urinary Indicator of Renal Failure in Humans and Animals Poisoned with Uranium

• Published in: Radiation protection dosimetry 1989-01, Vol.26 (1-4), p.113-117
• Main Authors: Hengé-Napoli, M.H., Rongier, E., Ansorbolo, E., Chalabreysse, J.
• Format: Article
• Language: English
• ISSN: 0144-8420; 1742-3406
• DOI: 10.1093/oxfordjournals.rpd.a080390

The objective of this study was to investigate the solubility of industrial calcined diuranate in various in vitro systems and to test the sensitivity of biological parameters in detecting renal alterations after intoxication in animals and in human subjects. The dissolution rates in in vitro static and dynamic tests are consistent for each solution for both types of test. The in vivo results are comparable to the in vitro results obtained with Gamble solution for both compounds. The excretion kinetics observed are compared with the values calculated from ICRP standards. Urinary GGT excretion measurements are found to be a satisfactory indicator of uranium-induced kidney alterations. GGT excretion increases for injected doses exceeding 50 µg.kg-1. Initial results in human subjects suggest that following accidental exposure to uranium, GGT is a more sensitive indicator of kidney damage than glycosuria.