Epstein–Barr virus and Hodgkin lymphoma in Jordan

Background and objectives This study aims to examine the possible association of Epstein–Barr virus (EBV) in Classical Hodgkin lymphoma (cHL) and to shed light on the epidemiology of Hodgkin lymphoma (HL) in Jordan. Patients and methods We examined 100 consecutive cases of HL for the presence of EBV...

Full description

Saved in:
Bibliographic Details
Published in:Hematology/oncology and stem cell therapy 2014-06, Vol.7 (2), p.85-89
Main Authors: Sughayer, Maher A, Haddad, Hussam A, Al-Yousef, Rana M, El-Khateeb, Mohammed, Abu-Rass, Hanood
Format: Article
Language:English
Subjects:
Adolescent
Adult
EBV
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - epidemiology
Female
Hematology, Oncology and Palliative Medicine
Hodgkin Disease - epidemiology
Hodgkin Disease - virology
Hodgkin lymphoma
Humans
Immunohistochemistry
Jordan
Jordan - epidemiology
Male
Middle Aged
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and objectives This study aims to examine the possible association of Epstein–Barr virus (EBV) in Classical Hodgkin lymphoma (cHL) and to shed light on the epidemiology of Hodgkin lymphoma (HL) in Jordan. Patients and methods We examined 100 consecutive cases of HL for the presence of EBV in tumor cells by immunohistochemistry for latent membrane protein-1 (LMP-1). We collected patient data on age, sex and histologic subtype. We reviewed the pathological findings in each case and confirmed diagnosis. Results Nodular lymphocyte predominant HL was diagnosed in 6% of the cases and these were negative for EBV LMP-1. Of the 94 cases of cHL, 65% were males, the most common subtype was nodular sclerosis (NS), representing 70% of the cases, and 45.7% of cHL (43% of all HL) cases were positive for EBV LMP-1. The positive cases were significantly related to age: ⩽15 years and >51 years ( p : 0.009 and 0.014 respectively), male gender ( p : 0.03) and mixed cellularity (MC) subtype ( p :
ISSN:1658-3876
DOI:10.1016/j.hemonc.2013.12.002