Structure-property relationships and biocompatibility of carbohydrate crosslinked polyurethanes

• Published in: Carbohydrate polymers 2014-09, Vol.110, p.338-344
• Main Authors: SOLANKI, Archana, MEHTA, Jayen, THAKORE, Sonal
• Format: Article
• Language: English
• Subjects: Applied sciences; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Carbohydrate Metabolism; Carbohydrates - chemistry; Castor Oil - chemistry; Castor Oil - metabolism; Cell Line; Cell Survival; Cross-Linking Reagents - chemistry; Cross-Linking Reagents - metabolism; Exact sciences and technology; Glucose - chemistry; Glucose - metabolism; Humans; Materials Testing; Mechanical properties; Organic polymers; Physicochemistry of polymers; Polymers - chemistry; Polymers - metabolism; Polyurethanes - chemistry; Polyurethanes - metabolism; Properties and characterization; Propylene Glycols - chemistry; Propylene Glycols - metabolism; Sucrose - chemistry; Sucrose - metabolism; Transition Temperature
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2014.04.021

Biocompatible and biodegradable polyurethanes (PUs) based on castor oil and polypropylene glycols (PPGs) were prepared using various carbohydrate crosslinkers: monosaccharide (glucose), disaccharide (sucrose) and polysaccharides (starch and cellulose). The mechanical and thermal properties were investigated and interpreted on the basis of SEM study. The advantage of incorporating various carbohydrates is to have tunable mechanical properties and biodegradability due to variety in their structure. The glass transition temperature and sorption behavior were dominated by the type of polyol than by the type of crosslinker. All the PUs were observed to be biodegradable as well as non-cytotoxic as revealed by MTT assay in normal lung cell line L132. The study supports the suitability of carbohydrates as important components of biocompatible PUs for development of biomedical devices.