In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction

• Published in: Carbohydrate polymers 2014-09, Vol.110, p.87-94
• Main Authors: Li, Yangling, Liu, Chang, Tan, Ying, Xu, Kun, Lu, Cuige, Wang, Pixin
• Format: Article
• Language: English
• Subjects: Applied sciences; Biological and medical sciences; Exact sciences and technology; General pharmacology; Hydrogels - chemical synthesis; Hydrogels - metabolism; Medical sciences; Nanoparticles - chemistry; Nanoparticles - metabolism; Natural polymers; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Properties and characterization; Schiff Bases - chemical synthesis; Schiff Bases - metabolism; Solution and gel properties; Starch - chemical synthesis; Starch - metabolism; Starch and polysaccharides
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2014.03.058

Polysaccharide-based hydrogels are remarkable materials for the biomedical fields because of its excellent biodegradation and biocompatibility. In this work, a novel polysaccharide-based hydrogel was fabricated by in situ crosslinking of starch-based nanoparticles and polyvinylamine. Starch was decorated with cholesterol group and aldehyde groups. TEM and DLS showed that the cholesterol modified oxidation starch (OCS) exhibited a core-shell nanoparticles with mean size of ∼143 nm in aqueous. The hydrogel was then synthesized via Schiff base reaction. Rheological measurements demonstrated the incorporation of cholesterol groups not only reduced the gel time but also improved the storage modulus of the hydrogel compared with the oxide starch crosslinked hydrogel. SEM showed the OCS based hydrogels possess a well-defined porous structure. Furthermore, doxorubicin (DOX) was used as model drug to investigate the control and release properties of OCS hydrogels. This OCS hydrogel would be a promising drug carrier for biomedical applications.