Mortality in hypertensive patients with coronary heart disease depends on chronopharmacotherapy and dipping status

The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality. Subjects with established coronary heart disease (CHD) (n=1345, mean age 63.2±9.2 years) were included. Non-dipping status was related to a lack of nighttime...

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Bibliographic Details
Published in:Pharmacological reports 2014-06, Vol.66 (3), p.448-452
Main Authors: Sobiczewski, Wojciech, Wirtwein, Marcin, Gruchała, Marcin, Kocić, Ivan
Format: Article
Language:English
Subjects:
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Blood Pressure - physiology
Blood pressure profile
Chronopharmacotherapy
Coronary Disease - physiopathology
Coronary heart disease
Drug Safety and Pharmacovigilance
Female
Humans
Hypertension
Hypertension - drug therapy
Hypertension - physiopathology
Male
Middle Aged
Non-dippers
Original Research Article
Pharmacotherapy
Pharmacy
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Summary:The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality. Subjects with established coronary heart disease (CHD) (n=1345, mean age 63.2±9.2 years) were included. Non-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00–4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02–1.47) and non-nighttime antihypertensive drug administration (HR 1.13, 95% CI 1.01–1.45) were predictors of all-cause mortality. The non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime.
ISSN:1734-1140
2299-5684
DOI:10.1016/j.pharep.2013.12.009