In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma

• Published in: Phytomedicine (Stuttgart) 2014-07, Vol.21 (8-9), p.1078-1087
• Main Authors: Luo, Ke-Wang, Yue, Grace Gar-Lee, Ko, Chun-Hay, Lee, Julia Kin-Ming, Gao, Si, Li, Long-Fei, Li, Gang, Fung, Kwok-Pui, Leung, Ping-Chung, Lau, Clara Bik-San
• Format: Article
• Language: English
• Subjects: 4T1 cells; Animals; Anti-metastasis; Anti-tumor; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Basidiomycota; Basidiomycota - chemistry; Biological products; Bone destruction; Bone Diseases - prevention & control; Breast cancer; Breast Neoplasms - complications; Breast Neoplasms - drug therapy; Carcinoma - drug therapy; Carcinoma - secondary; Care and treatment; Cell Extracts - isolation & purification; Cell Extracts - pharmacology; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Coriolus versicolor; Cytokines - drug effects; Disease Models, Animal; Female; Health aspects; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Metastasis; Mice; Neoplasm Metastasis - prevention & control
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2014.04.020

Coriolus versicolor (CV), a medicinal mushroom widely consumed in Asian countries, has been demonstrated to be effective in stimulation of immune system and inhibition of tumor growth. The present study aimed to investigate the anti-tumor and anti-metastasis effects of CV aqueous extract in mouse mammary carcinoma 4T1 cells and in 4T1-tumor bearing mouse model. Our results showed that CV aqueous extract (0.125–2mg/ml) did not inhibit 4T1 cell proliferation while the non-cytotoxic dose of CV extract (1–2mg/ml) significantly inhibited cell migration and invasion (p