Interaction between latent papovavirus genomes and the tumor promoter TPA

The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances both the transformation of rat embryo cells by adenovirus and the cloning efficiency of such cells. Induction of Epstein-Barr virus (EBV) antigens and stimulation of particle synthesis by treatment of the EBV-carrying cell...

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Bibliographic Details
Published in:FEBS letters 1981-06, Vol.128 (2), p.191-194
Main Authors: Krieg, Peter, Amtmann, Eberhard, Sauer, Gerhard
Format: Article
Language:English
Subjects:
Cell Transformation, Viral - drug effects
DNA, Viral - biosynthesis
Papillomaviridae - genetics
Phorbols - pharmacology
Plasmids - drug effects
Polyomaviridae
stump-tailed macaque virus
Tetradecanoylphorbol Acetate - pharmacology
Virus Replication - drug effects
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Summary:The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances both the transformation of rat embryo cells by adenovirus and the cloning efficiency of such cells. Induction of Epstein-Barr virus (EBV) antigens and stimulation of particle synthesis by treatment of the EBV-carrying cell lines with TPA was previously reported. Here the authors report that TPA exclusively enhances the viral DNA content of cells which harbor papovavirus genomes in a latent episomal state. On the other hand, no effect is exerted by TPA on the copy number of the viral DNA in productively infected cells and on integrated papovavirus DNA in transformed cells.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(81)80078-6