Cycloartane-type triterpene glycosides from Beesia calthaefolia and their anticomplement activity

Two new 9,19-cycloartane triterpenes (1, 2), together with three known compounds (3–5), were isolated from the whole plant of Beesia calthaefolia. Their structures were determined by the application of spectroscopic analyses and chemical methods. Compound 1 showed moderate anticomplement activity si...

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Bibliographic Details
Published in:Journal of natural medicines 2014-07, Vol.68 (3), p.604-609
Main Authors: Mu, Li-Hua, Li, Hong-Jie, Guo, Dai-Hong, Zhao, Jin-Yuan, Liu, Ping
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
chemical analysis
Complement Inactivating Agents - chemistry
Complement Inactivating Agents - pharmacology
Complementary & Alternative Medicine
glycosides
Glycosides - chemistry
Glycosides - pharmacology
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Ranunculaceae - chemistry
rosmarinic acid
spectroscopy
Triterpenes - chemistry
Triterpenes - pharmacology
triterpenoids
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Summary:Two new 9,19-cycloartane triterpenes (1, 2), together with three known compounds (3–5), were isolated from the whole plant of Beesia calthaefolia. Their structures were determined by the application of spectroscopic analyses and chemical methods. Compound 1 showed moderate anticomplement activity similar to that of the positive control (rosmarinic acid), while compounds 3 and 4 showed weak activity. The results suggest that 6′-O-(4″-hydroxy-3″-methoxy-benzoyl)-β-D-glucosyl of 9,19-cycloartane-type triterpenoids could be a structure that is essential for anticomplement activity.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-014-0820-5