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Inpatient survival after gastrectomy for gastric cancer in the 21st century

Abstract Background Surgical treatment for gastric cancer has evolved substantially. To understand how changes in patient- and hospital-level factors are associated with outcomes over the last decade, we examined a nationally representative sample. Methods Retrospective cross-sectional discharge dat...

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Published in:The Journal of surgical research 2014-07, Vol.190 (1), p.72-78
Main Authors: Wang, Han, MD, MPH, Pawlik, Timothy M., MD, MPH, PhD, Duncan, Mark D., MD, Hui, Xuan, MD, ScM, Selvarajah, Shalini, MD, MPH, Canner, Joseph K., MHS, Haider, Adil H., MD, MPH, Ahuja, Nita, MD, Schneider, Eric B., PhD
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cited_by cdi_FETCH-LOGICAL-c408t-85e2bca822a953d28009d4c821d471191373cc0104a2c6b035f7afa9275803e63
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container_title The Journal of surgical research
container_volume 190
creator Wang, Han, MD, MPH
Pawlik, Timothy M., MD, MPH, PhD
Duncan, Mark D., MD
Hui, Xuan, MD, ScM
Selvarajah, Shalini, MD, MPH
Canner, Joseph K., MHS
Haider, Adil H., MD, MPH
Ahuja, Nita, MD
Schneider, Eric B., PhD
description Abstract Background Surgical treatment for gastric cancer has evolved substantially. To understand how changes in patient- and hospital-level factors are associated with outcomes over the last decade, we examined a nationally representative sample. Methods Retrospective cross-sectional discharge data from the 2001–2010 Nationwide Inpatient Sample were analyzed using cross tabulation and multivariable regression modeling. Patients with a primary diagnosis of gastric cancer undergoing gastrectomy as primary procedure were included. We examined relationships between patient- and hospital-level factors, surgery type, and outcomes including in-hospital mortality and length of stay (LOS). Results A total of 67,327 patients with gastric cancer undergoing gastrectomy nationwide with complete information were included. Compared with patients treated in 2001, patients in 2010 were younger, more likely admitted electively, treated in a teaching hospital, or at an urban center. There was no difference in the type of procedure performed over time. Factors associated with an increased risk of in-hospital mortality included older age, male gender, and nonelective admission ( P  
doi_str_mv 10.1016/j.jss.2014.03.015
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To understand how changes in patient- and hospital-level factors are associated with outcomes over the last decade, we examined a nationally representative sample. Methods Retrospective cross-sectional discharge data from the 2001–2010 Nationwide Inpatient Sample were analyzed using cross tabulation and multivariable regression modeling. Patients with a primary diagnosis of gastric cancer undergoing gastrectomy as primary procedure were included. We examined relationships between patient- and hospital-level factors, surgery type, and outcomes including in-hospital mortality and length of stay (LOS). Results A total of 67,327 patients with gastric cancer undergoing gastrectomy nationwide with complete information were included. Compared with patients treated in 2001, patients in 2010 were younger, more likely admitted electively, treated in a teaching hospital, or at an urban center. There was no difference in the type of procedure performed over time. Factors associated with an increased risk of in-hospital mortality included older age, male gender, and nonelective admission ( P  &lt; 0.05). In multivariable analysis, patients undergoing gastrectomy in 2010 demonstrated 40% lower odds of in-hospital mortality (odds ratio, 0.60; P  = 0.008). Overall mean LOS was 13.9 d (standard error, 0.1) without change over time. Factors associated with longer LOS included procedure type, hospital location, nonelective admission, and comorbid disease (all P  &lt; 0.05). Conclusions The adjusted odds of in-hospital mortality among surgically treated patients with gastric cancer decreased &gt;40% between 2001 and 2010. Further research is warranted to determine if these findings are due to better patient selection, regionalization of care, or improvement of in-hospital quality of care.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2014.03.015</identifier><identifier>PMID: 24725677</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Cross-Sectional Studies ; Female ; Gastrectomy ; Gastrectomy - mortality ; Gastric cancer ; Hospital Mortality ; Humans ; Inpatients ; Male ; Retrospective Studies ; Stomach Neoplasms - surgery ; Surgery ; Survival ; Variation</subject><ispartof>The Journal of surgical research, 2014-07, Vol.190 (1), p.72-78</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-85e2bca822a953d28009d4c821d471191373cc0104a2c6b035f7afa9275803e63</citedby><cites>FETCH-LOGICAL-c408t-85e2bca822a953d28009d4c821d471191373cc0104a2c6b035f7afa9275803e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24725677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Han, MD, MPH</creatorcontrib><creatorcontrib>Pawlik, Timothy M., MD, MPH, PhD</creatorcontrib><creatorcontrib>Duncan, Mark D., MD</creatorcontrib><creatorcontrib>Hui, Xuan, MD, ScM</creatorcontrib><creatorcontrib>Selvarajah, Shalini, MD, MPH</creatorcontrib><creatorcontrib>Canner, Joseph K., MHS</creatorcontrib><creatorcontrib>Haider, Adil H., MD, MPH</creatorcontrib><creatorcontrib>Ahuja, Nita, MD</creatorcontrib><creatorcontrib>Schneider, Eric B., PhD</creatorcontrib><title>Inpatient survival after gastrectomy for gastric cancer in the 21st century</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Abstract Background Surgical treatment for gastric cancer has evolved substantially. To understand how changes in patient- and hospital-level factors are associated with outcomes over the last decade, we examined a nationally representative sample. Methods Retrospective cross-sectional discharge data from the 2001–2010 Nationwide Inpatient Sample were analyzed using cross tabulation and multivariable regression modeling. Patients with a primary diagnosis of gastric cancer undergoing gastrectomy as primary procedure were included. We examined relationships between patient- and hospital-level factors, surgery type, and outcomes including in-hospital mortality and length of stay (LOS). Results A total of 67,327 patients with gastric cancer undergoing gastrectomy nationwide with complete information were included. Compared with patients treated in 2001, patients in 2010 were younger, more likely admitted electively, treated in a teaching hospital, or at an urban center. There was no difference in the type of procedure performed over time. Factors associated with an increased risk of in-hospital mortality included older age, male gender, and nonelective admission ( P  &lt; 0.05). In multivariable analysis, patients undergoing gastrectomy in 2010 demonstrated 40% lower odds of in-hospital mortality (odds ratio, 0.60; P  = 0.008). Overall mean LOS was 13.9 d (standard error, 0.1) without change over time. Factors associated with longer LOS included procedure type, hospital location, nonelective admission, and comorbid disease (all P  &lt; 0.05). Conclusions The adjusted odds of in-hospital mortality among surgically treated patients with gastric cancer decreased &gt;40% between 2001 and 2010. Further research is warranted to determine if these findings are due to better patient selection, regionalization of care, or improvement of in-hospital quality of care.</description><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastrectomy - mortality</subject><subject>Gastric cancer</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Inpatients</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Survival</subject><subject>Variation</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxS1ERbeFD8AF5cglYcZ_4kRISKiCtmolDsDZ8joTcMgmi-2stN8eR7tw6IHTzGjee9L8hrHXCBUC1u-Gaoix4oCyAlEBqmdsg9Cqsqm1eM42AJyXsgF5ya5iHCDPrRYv2CWXmqta6w17uJ_2NnmaUhGXcPAHOxa2TxSKHzamQC7Nu2PRz-fZu8LZyeW1n4r0kwqOMRUu25dwfMkuejtGenWu1-z750_fbu7Kxy-39zcfH0snoUllo4hvnW04t60SHW8A2k66hmMnNWKLQgvnAEFa7uotCNVr29uWa9WAoFpcs7en3H2Yfy8Uk9n56Ggc7UTzEg0qIXXLFYosxZPUhTnGQL3ZB7-z4WgQzMrQDCYzNCtDA8Jkhtnz5hy_bHfU_XP8hZYF708CykcePAUTXSboqPMrMNPN_r_xH5643egn7-z4i44Uh3kJU6Zn0ERuwHxdn7j-EGXuciP-ALPRlWk</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Wang, Han, MD, MPH</creator><creator>Pawlik, Timothy M., MD, MPH, PhD</creator><creator>Duncan, Mark D., MD</creator><creator>Hui, Xuan, MD, ScM</creator><creator>Selvarajah, Shalini, MD, MPH</creator><creator>Canner, Joseph K., MHS</creator><creator>Haider, Adil H., MD, MPH</creator><creator>Ahuja, Nita, MD</creator><creator>Schneider, Eric B., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Inpatient survival after gastrectomy for gastric cancer in the 21st century</title><author>Wang, Han, MD, MPH ; Pawlik, Timothy M., MD, MPH, PhD ; Duncan, Mark D., MD ; Hui, Xuan, MD, ScM ; Selvarajah, Shalini, MD, MPH ; Canner, Joseph K., MHS ; Haider, Adil H., MD, MPH ; Ahuja, Nita, MD ; Schneider, Eric B., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-85e2bca822a953d28009d4c821d471191373cc0104a2c6b035f7afa9275803e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastrectomy - mortality</topic><topic>Gastric cancer</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Inpatients</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Survival</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Han, MD, MPH</creatorcontrib><creatorcontrib>Pawlik, Timothy M., MD, MPH, PhD</creatorcontrib><creatorcontrib>Duncan, Mark D., MD</creatorcontrib><creatorcontrib>Hui, Xuan, MD, ScM</creatorcontrib><creatorcontrib>Selvarajah, Shalini, MD, MPH</creatorcontrib><creatorcontrib>Canner, Joseph K., MHS</creatorcontrib><creatorcontrib>Haider, Adil H., MD, MPH</creatorcontrib><creatorcontrib>Ahuja, Nita, MD</creatorcontrib><creatorcontrib>Schneider, Eric B., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Han, MD, MPH</au><au>Pawlik, Timothy M., MD, MPH, PhD</au><au>Duncan, Mark D., MD</au><au>Hui, Xuan, MD, ScM</au><au>Selvarajah, Shalini, MD, MPH</au><au>Canner, Joseph K., MHS</au><au>Haider, Adil H., MD, MPH</au><au>Ahuja, Nita, MD</au><au>Schneider, Eric B., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inpatient survival after gastrectomy for gastric cancer in the 21st century</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>190</volume><issue>1</issue><spage>72</spage><epage>78</epage><pages>72-78</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>Abstract Background Surgical treatment for gastric cancer has evolved substantially. To understand how changes in patient- and hospital-level factors are associated with outcomes over the last decade, we examined a nationally representative sample. Methods Retrospective cross-sectional discharge data from the 2001–2010 Nationwide Inpatient Sample were analyzed using cross tabulation and multivariable regression modeling. Patients with a primary diagnosis of gastric cancer undergoing gastrectomy as primary procedure were included. We examined relationships between patient- and hospital-level factors, surgery type, and outcomes including in-hospital mortality and length of stay (LOS). Results A total of 67,327 patients with gastric cancer undergoing gastrectomy nationwide with complete information were included. Compared with patients treated in 2001, patients in 2010 were younger, more likely admitted electively, treated in a teaching hospital, or at an urban center. There was no difference in the type of procedure performed over time. Factors associated with an increased risk of in-hospital mortality included older age, male gender, and nonelective admission ( P  &lt; 0.05). In multivariable analysis, patients undergoing gastrectomy in 2010 demonstrated 40% lower odds of in-hospital mortality (odds ratio, 0.60; P  = 0.008). Overall mean LOS was 13.9 d (standard error, 0.1) without change over time. Factors associated with longer LOS included procedure type, hospital location, nonelective admission, and comorbid disease (all P  &lt; 0.05). Conclusions The adjusted odds of in-hospital mortality among surgically treated patients with gastric cancer decreased &gt;40% between 2001 and 2010. Further research is warranted to determine if these findings are due to better patient selection, regionalization of care, or improvement of in-hospital quality of care.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24725677</pmid><doi>10.1016/j.jss.2014.03.015</doi><tpages>7</tpages></addata></record>
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subjects Aged
Cross-Sectional Studies
Female
Gastrectomy
Gastrectomy - mortality
Gastric cancer
Hospital Mortality
Humans
Inpatients
Male
Retrospective Studies
Stomach Neoplasms - surgery
Surgery
Survival
Variation
title Inpatient survival after gastrectomy for gastric cancer in the 21st century
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