Immune response to Bordetella pertussis is associated with season and undernutrition in Senegalese children

Highlights • Birth season and undernutrition modulated children's humoral response to pertussis toxin. • Response to Bordetella pertussis was dependent on age, village and time of visit. • Environmental factors modulate children's response to pertussis infection or vaccination.

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Bibliographic Details
Published in:Vaccine 2014-06, Vol.32 (27), p.3431-3437
Main Authors: Gaayeb, Lobna, Pinçon, Claire, Cames, Cécile, Sarr, Jean-Biram, Seck, Modou, Schacht, Anne-Marie, Remoué, Franck, Hermann, Emmanuel, Riveau, Gilles
Format: Article
Language:English
Subjects:
Africa
Allergy and Immunology
Anthropometry
Antibodies, Bacterial - blood
Applied microbiology
Bacteriology
Biological and medical sciences
Birth season
Bordetella pertussis
Child
Child, Preschool
Environment
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunity
Immunity, Humoral
Immunoglobulin G - blood
Infant
Longitudinal Studies
Male
Malnutrition
Malnutrition - immunology
Microbiology
Miscellaneous
Multivariate Analysis
Nutritional Status
Pertussis Toxin - immunology
Pertussis Vaccine - immunology
Seasons
Senegal
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Description
Summary:Highlights • Birth season and undernutrition modulated children's humoral response to pertussis toxin. • Response to Bordetella pertussis was dependent on age, village and time of visit. • Environmental factors modulate children's response to pertussis infection or vaccination.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.03.086