Hippocampal vulnerability and subacute response following varied blast magnitudes

•Low, moderate and high blast pressures (69, 97 and 165kPa respectively) were used to establish molecular injury thresholds.•Gene expression using Real Time PCR and protein expression using immunohistochemistry were performed at 7 days post blast.•GLAST gene expression was up regulated in the low pr...

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Bibliographic Details
Published in:Neuroscience letters 2014-06, Vol.570, p.33-37
Main Authors: Sajja, Venkata Siva Sai Sujith, Ereifej, Evon S., VandeVord, Pamela J.
Format: Article
Language:English
Subjects:
Animals
Blast
Blast Injuries - metabolism
Brain-Derived Neurotrophic Factor - metabolism
Head Injuries, Closed - metabolism
Hippocampus
Hippocampus - metabolism
Inflammation - metabolism
Interleukin-3 - metabolism
Magnitude
Male
Oxidative Stress
Piezo2
Pressure
Rats, Sprague-Dawley
Receptors, Glutamate - metabolism
Signal Transduction
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Summary:•Low, moderate and high blast pressures (69, 97 and 165kPa respectively) were used to establish molecular injury thresholds.•Gene expression using Real Time PCR and protein expression using immunohistochemistry were performed at 7 days post blast.•GLAST gene expression was up regulated in the low pressure group but down regulated in the high pressure group.•Map2k1 and mechanosensitive protein Piezo 2 expression was increased at moderate blast level.•Neuroprotection (BDNF and GDNF) was observed with low and moderate blast levels. Clinical outcomes from blast neurotrauma are associated with higher order cognitive functions such as memory, problem solving skills and attention. Current literature is limited to a single overpressure exposure or repeated exposures at the same level of overpressure and is focused on the acute response (
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2014.03.072