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Reporting an outbreak of Candida pelliculosa fungemia in a neonatal intensive care unit

Background Fungemia in preterm infants is associated with high mortality and morbidity. This study reports an outbreak of unusual fungemia in a tertiary neonatal intensive care unit (NICU). Methods Ten Candida pelliculosa bloodstream isolates were identified from six infants hospitalized in the NICU...

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Published in:Journal of microbiology, immunology and infection immunology and infection, 2013-12, Vol.46 (6), p.456-462
Main Authors: Lin, Hsiao-Chuan, Lin, Hsiang-Yu, Su, Bai-Hong, Ho, Mao-Wang, Ho, Cheng-Mao, Lee, Ching-Yi, Lin, Ming-Hsia, Hsieh, Hsin-Yang, Lin, Hung-Chih, Li, Tsai-Chung, Hwang, Kao-Pin, Lu, Jang-Jih
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Language:English
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Summary:Background Fungemia in preterm infants is associated with high mortality and morbidity. This study reports an outbreak of unusual fungemia in a tertiary neonatal intensive care unit (NICU). Methods Ten Candida pelliculosa bloodstream isolates were identified from six infants hospitalized in the NICU from February to March 2009. Environmental study was performed, and genetic relatedness among the 10 clinical isolates of C pelliculosa and six control C pelliculosa strains was characterized by randomly amplified polymorphic DNA assay. In vitro susceptibility of isolates to six antifungal agents was analyzed by broth microdilution method. Amphotericin B was given to infected infants and prophylactic fluconazole was prescribed to the other noninfected extremely low birth weight infants during the outbreak. Results Thrombocytopenia (platelet counts
ISSN:1684-1182
1995-9133
DOI:10.1016/j.jmii.2012.07.013